Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872362 | 0.90 | ALDH1A1 (0.52) | MCHR1ADRA2AEPHX1ALDH1A1GAA | |
| SCHEMBL6880541 | 0.90 | MCHR1 (0.41) | MCHR1ADRA2AALDH1A1MEN1MAPT | |
| SCHEMBL6458289 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AALDH1A1MEN1MAPT | |
| SCHEMBL6458281 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AALDH1A1MEN1MAPT | |
| SCHEMBL6881237 | 0.84 | MCHR1 (0.46) | MCHR1ADRA2AEPHX1MEN1KMT2A | |
| SCHEMBL6881234 | 0.84 | MCHR1 (0.46) | MCHR1ADRA2AEPHX1MEN1KMT2A | |
| SCHEMBL4030186 | 0.84 | MCHR1 (0.64) | MCHR1ADRA2AALDH1A1GAA | |
| SCHEMBL4030189 | 0.84 | MCHR1 (0.64) | MCHR1ADRA2AALDH1A1GAA | |
| SCHEMBL6873180 | 0.82 | MCHR1 (0.43) | MCHR1ADRA2AALDH1A1MEN1MAPT | |
| SCHEMBL6873170 | 0.82 | MCHR1 (0.43) | MCHR1ADRA2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |