Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 7/20 | 0.45 |
| ▸ | CTSA | P10619 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687209 | 0.90 | CYP2C19 (0.50) | CTSAALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL688412 | 0.85 | ALDH1A1 (0.47) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7383966 | 0.82 | CTSA (0.47) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL687891 | 0.82 | PTGER3 (0.69) | PTGER3MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL687707 | 0.81 | PTGER3 (0.58) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL687963 | 0.80 | PTGER3 (0.46) | PTGER3CTSAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL686808 | 0.80 | CTSA (0.42) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL687079 | 0.80 | PTGER3 (0.43) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL686693 | 0.79 | PTGER3 (0.42) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL687879 | 0.78 | CTSA (0.41) | PTGER3CTSAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |