Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687631 | 0.94 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2APOLBLMNAALDH1A1 | |
| SCHEMBL693144 | 0.91 | KDM4E (0.37) | SMN1; SMN2KMT2AITGB1ITGA4ALDH1A1 | |
| SCHEMBL687242 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2APOLBLMNAITGB1 | |
| SCHEMBL687082 | 0.89 | POLB (0.39) | SMN1; SMN2KMT2APOLBITGB1ITGA4 | |
| SCHEMBL688220 | 0.88 | SLC22A12 (0.36) | KMT2AITGB1ITGA4ALDH1A1KDM4E | |
| SCHEMBL686989 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2APOLBITGB1ITGA4 | |
| SCHEMBL687715 | 0.88 | CTSA (0.39) | SMN1; SMN2KMT2APOLBITGB1ITGA4 | |
| SCHEMBL688386 | 0.88 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2APOLBITGB1ITGA4 | |
| SCHEMBL687967 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2APOLBLMNAITGB1 | |
| SCHEMBL27741938 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2APOLBLMNAITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |