Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688146 | 0.92 | CTSA (0.41) | SLC22A12CYP26A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL688358 | 0.91 | POLB (0.39) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL687082 | 0.91 | POLB (0.39) | CYP26A1KDM4EALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL688170 | 0.89 | PTGER3 (0.41) | SLC22A12CYP26A1KDM4EALDH1A1ITGB1 | |
| SCHEMBL687310 | 0.88 | CTSA (0.39) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL688167 | 0.88 | SMN1; SMN2 (0.43) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL693144 | 0.88 | KDM4E (0.37) | SLC22A12KDM4EALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL688046 | 0.88 | CTSA (0.42) | SLC22A12CYP26A1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL688149 | 0.88 | PDE4A (0.38) | SLC22A12KDM4EALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL688327 | 0.88 | SLC22A12 (0.34) | SLC22A12CYP26A1KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |