Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486451 | 0.87 | PDE4A (0.55) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL6889940 | 0.83 | PDE4B (0.43) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL6758010 | 0.82 | PDE4A (0.51) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL5818764 | 0.79 | PDE4A (0.76) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL27548932 | 0.79 | PDE4A (0.49) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL6881800 | 0.79 | PDE4A (0.48) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL6881797 | 0.79 | PDE4A (0.48) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| Hydrochloric Acid SCHEMBL8202348 | 0.78 | PDE4A (0.74) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL6886585 | 0.78 | PDE4A (0.45) | PDE4AS1PR1S1PR3PDE4DPDE4B | |
| SCHEMBL7845534 | 0.75 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | claimed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | claimed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | disclosed |
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |