Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.43 |
| ▸ | PDE4A | P27815 | 12/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882236 | 0.83 | PDE4A (0.55) | PDE4BPDE4APDE4DPDE4CS1PR1 | |
| SCHEMBL7486451 | 0.71 | PDE4A (0.55) | PDE4BPDE4APDE4DPDE4CS1PR1 | |
| SCHEMBL7845534 | 0.70 | PDE4A (0.56) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL4189274 | 0.69 | POLB (0.54) | PDE4BPDE4APDE4DPDE4CEPHX2 | |
| SCHEMBL27548932 | 0.68 | PDE4A (0.49) | PDE4BPDE4APDE4DPDE4CS1PR1 | |
| Formic Acid SCHEMBL8693256 | 0.67 | PDE4A (0.71) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL6881800 | 0.67 | PDE4A (0.48) | PDE4BPDE4APDE4DPDE4CS1PR1 | |
| SCHEMBL6881797 | 0.67 | PDE4A (0.48) | PDE4BPDE4APDE4DPDE4CS1PR1 | |
| SCHEMBL7442784 | 0.67 | PDE4B (0.66) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL5823060 | 0.67 | PDE4A (0.77) | PDE4BPDE4APDE4DPDE4CS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770065-B1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-03-31 | — | — | EP | disclosed |
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |