Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046873 | 0.80 | PDE11A (0.37) | PDE11AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL5872104 | 0.79 | GAA (0.45) | PDE11AKDM4ENPC1HSD17B10GAA | |
| SCHEMBL5872280 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAASMN1; SMN2LMNA | |
| SCHEMBL8287549 | 0.78 | PDE11A (0.39) | PDE11AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL7036674 | 0.77 | ALDH1A1 (0.41) | PDE11AMAPTALDH1A1GAAHPGD | |
| SCHEMBL5872094 | 0.77 | PDE11A (0.40) | PDE11AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL8286548 | 0.76 | SMN1; SMN2 (0.50) | MAPTNPC1GAAMAPK1SMN1; SMN2 | |
| SCHEMBL5871645 | 0.76 | GAA (0.42) | PDE11AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL5871665 | 0.76 | GAA (0.36) | PDE11AKDM4EGAAGFERHPGD | |
| SCHEMBL8287221 | 0.76 | APLNR (0.42) | PDE11AMAPTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1578781-A | 1, 8-naphthyridine derivatives useful as antidiabetic agents | BAYER PHARMACEUTICALS CORP (US) | 2005-02-09 | — | — | CN | disclosed |
| CN-1578780-A | 1, 6-naphthyridine derivatives useful as antidiabetic agents | BAYER PHARMACEUTICALS CORP (US) | 2005-02-09 | — | — | CN | disclosed |
| US-6677352-B1 | 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-01-13 | — | — | US | disclosed |