Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DVL1 | O14640 | 1/20 | 0.35 |
| ▸ | DVL3 | Q92997 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30282651 | 0.91 | SIRT1 (0.44) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL28655045 | 0.91 | SIRT1 (0.44) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL28659051 | 0.90 | SIRT1 (0.43) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL28654122 | 0.90 | SIRT1 (0.43) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL30282777 | 0.80 | SIRT1 (0.42) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL28655392 | 0.80 | SIRT1 (0.42) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL30282721 | 0.80 | SIRT1 (0.42) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL30282855 | 0.79 | SIRT1 (0.44) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL28649772 | 0.79 | SIRT1 (0.44) | MEN1KMT2AATML3MBTL1SIRT1 | |
| SCHEMBL30282731 | 0.79 | MEN1 (0.50) | DVL1DVL3MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |