Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640571 | 1.00 | BTK (0.65) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6828924 | 1.00 | BTK (0.65) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6883716 | 1.00 | BTK (0.65) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6640171 | 1.00 | BTK (0.65) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6643451 | 0.91 | BTK (0.56) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL16856527 | 0.91 | BTK (0.56) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL3900948 | 0.91 | BTK (0.56) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6451887 | 0.87 | BTK (0.63) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6878689 | 0.87 | BTK (0.59) | BTKKMT2AL3MBTL1EPHX1CA1 | |
| SCHEMBL6878692 | 0.87 | BTK (0.59) | BTKKMT2AL3MBTL1EPHX1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | BTK 3824/4885KMT2A 4610/4885L3MBTL1 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.