Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 6/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | IDE | P14735 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578177 | 0.91 | TDP1 (0.54) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL2513356 | 0.91 | TDP1 (0.67) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL2514439 | 0.91 | TDP1 (0.67) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL3120163 | 0.91 | TDP1 (0.54) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL9241448 | 0.90 | TDP1 (0.61) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL712974 | 0.89 | HLCS (0.62) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL6883588 | 0.89 | TDP1 (0.52) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL4295408 | 0.89 | TDP1 (0.52) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL2439518 | 0.88 | HLCS (0.67) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL8760672 | 0.87 | TDP1 (0.63) | HLCSTDP1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825331-B2 | DIAGNOSTIC HYBRIDIZATION PROBES; BIOCHEMICAL CONJUGATION | ISIS PHARMACEUTICALS, INC. | 2004-11-30 | — | — | US | disclosed |