Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444032 | 0.74 | SRD5A1 (0.44) | KCNH2HTR2AHTR2CSRD5A1TMEM97 | |
| SCHEMBL6885791 | 0.70 | HTR2A (0.34) | HTR2AHTR2CMAOB | |
| SCHEMBL6884068 | 0.70 | MAOB (0.36) | KCNH2MAOBMEN1KMT2A | |
| SCHEMBL8707542 | 0.68 | SRD5A1 (0.40) | KCNH2HTR2AHTR2CSRD5A1SLC6A2 | |
| SCHEMBL8356066 | 0.68 | SRD5A1 (0.46) | HTR2AHTR2CSRD5A1MAOBSLC6A2 | |
| SCHEMBL6885233 | 0.68 | SRD5A1 (0.46) | HTR2AHTR2CSRD5A1MAOBSLC6A2 | |
| SCHEMBL8355719 | 0.68 | SRD5A1 (0.46) | HTR2AHTR2CSRD5A1MAOBSLC6A2 | |
| SCHEMBL2381148 | 0.67 | SRD5A1 (0.39) | SRD5A1MAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22508495 | 0.66 | AURKA (0.38) | SRD5A1MAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22508496 | 0.66 | AURKA (0.38) | SRD5A1MAOBSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144296-A1 | DEUTERATED TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2017-03-22 | — | — | EP | disclosed |
| US-9273009-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140155444-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2014-06-05 | — | — | US | disclosed |
| US-8575361-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8513434-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2013-08-20 | — | — | US | disclosed |
| WO-2013036434-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS T-TYPE CALCIUM CHANNEL BLOCKER | CONCERT PHARMACEUTICALS INC. (US) | 2013-03-14 | — | — | WO | disclosed |
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110237635-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2011-09-29 | — | — | US | disclosed |
| WO-2011109464-A1 | DEUTERATED TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155444-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | KCNH2 38/4885HTR2A 270/4885HTR2C 364/4885 |
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | KCNH2 38/4885HTR2A 270/4885HTR2C 364/4885 |
| US-20110237635-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | KCNH2 38/4885HTR2A 270/4885HTR2C 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.