Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.56 |
| ▸ | BCL2 | P10415 | 4/20 | 0.55 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.55 |
| ▸ | BAD | Q92934 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 2/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6884106 | 1.00 | ADAMTS5 (0.60) | ADAMTS5PTPN1BCL2BCL2L2BAD | |
| SCHEMBL7145081 | 0.88 | ADAMTS5 (0.61) | ADAMTS5PTPN1BCL2BCL2L2BAD | |
| SCHEMBL7148343 | 0.87 | ADAMTS5 (0.71) | ADAMTS5PTPN1MAPTMEN1KMT2A | |
| SCHEMBL7165592 | 0.87 | MAPT (0.66) | ADAMTS5PTPN1BCL2BCL2L2BAD | |
| SCHEMBL7149413 | 0.85 | ADAMTS5 (0.62) | ADAMTS5PTPN1BCL2BCL2L2BAD | |
| SCHEMBL7147356 | 0.83 | PTPN1 (0.73) | ADAMTS5PTPN1MEN1KMT2APOLB | |
| SCHEMBL7140621 | 0.82 | MAPT (0.68) | ADAMTS5PTPN1MAPTMEN1KMT2A | |
| SCHEMBL7401104 | 0.81 | KMT2A (0.73) | ADAMTS5PTPN1MEN1KMT2APOLB | |
| SCHEMBL7149430 | 0.81 | PTPN1 (0.54) | ADAMTS5PTPN1MAPTMEN1KMT2A | |
| SCHEMBL7149409 | 0.81 | ADAMTS5 (0.68) | ADAMTS5PTPN1BCL2BCL2L2BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673816-B1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | Esswein, Angelika (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-1117655-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | Esswein, Angelika (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018747-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |