Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.67 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.64 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.62 |
| ▸ | CDC25B | P30305 | 1/20 | 0.62 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.62 |
| ▸ | BCL2 | P10415 | 4/20 | 0.61 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.61 |
| ▸ | BAD | Q92934 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165592 | 0.94 | MAPT (0.66) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL7146810 | 0.88 | PTPN1 (0.54) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL7148425 | 0.83 | ADAMTS5 (0.75) | ADAMTS5MAPTPOLBPTPN1BCL2 | |
| SCHEMBL7140621 | 0.82 | MAPT (0.68) | ADAMTS5MAPTPOLBPTPN1PTPN2 | |
| SCHEMBL7149886 | 0.82 | ADAMTS5 (0.65) | ADAMTS5MAPTPOLBPTPN1BCL2 | |
| SCHEMBL7149430 | 0.82 | PTPN1 (0.54) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL28506926 | 0.82 | MAPT (0.70) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL28506925 | 0.82 | MAPT (0.70) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL5218101 | 0.81 | ADAMTS5 (1.00) | ADAMTS5MAPTPOLBPLA2G1BATG4B | |
| SCHEMBL6884103 | 0.81 | ADAMTS5 (0.60) | ADAMTS5MAPTPOLBPTPN1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506755-B2 | 5-((2,4-bis-(4-methylphenylmethoxy)phenyl)methylene)-4-oxo-2-thioxo-3 -thiazolidineacetic acid, for example; treatment and prophylaxis of tumors and tumor metastasis | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |
| US-20020037901-A1 | Thiazolidinecarboxyl acids | HOFFMANN-LA ROCHE INC. | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037901-A1 | Thiazolidinecarboxyl acids | TPMT, NAT1, THRA | ADAMTS5 2515/4885MAPT 3924/4885POLB 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.