Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11407341 | 0.92 | TSHR (0.54) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL9232024 | 0.91 | TSHR (0.47) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL8595649 | 0.91 | TSHR (0.47) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL6884766 | 0.87 | TSHR (0.44) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL6887838 | 0.85 | TSHR (0.49) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL6882311 | 0.85 | LMNA (0.42) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL8593099 | 0.82 | TSHR (0.47) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL8595566 | 0.82 | TSHR (0.47) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL15669367 | 0.81 | MEN1 (0.48) | ALDH1A1LMNAMAPTTP53TDP1 | |
| SCHEMBL8596741 | 0.79 | TSHR (0.44) | ALDH1A1LMNAMAPTTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |