Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.39 |
| ▸ | CA1 | P00915 | 7/20 | 0.39 |
| ▸ | CA2 | P00918 | 7/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA5A | P35218 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232024 | 1.00 | TSHR (0.47) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL8595566 | 0.92 | TSHR (0.47) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6884785 | 0.91 | ALDH1A1 (0.52) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL11407341 | 0.91 | TSHR (0.54) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6884766 | 0.86 | TSHR (0.44) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL9229023 | 0.85 | TSHR (0.43) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL6887838 | 0.84 | TSHR (0.49) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL9232014 | 0.84 | TSHR (0.48) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL1846805 | 0.84 | TSHR (0.52) | TSHRALDH1A1LMNAMAPTTP53 | |
| SCHEMBL8593099 | 0.81 | TSHR (0.47) | TSHRALDH1A1LMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670845-B1 | PROCESS FOR THE PREPARATION OF FLUDARABINE PHOSPHATE FROM GUANOSINE | SCHERING AG (DE) | 1998-01-14 | — | — | EP | disclosed |
| US-5668270-A | Process for the preparation of fludarabine or fludarabine phosphate from guanosine | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-09-16 | — | — | US | disclosed |
| US-5602246-A | Process for the preparation of fludarabine or fludarabine phosphate from guanosine | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-02-11 | — | — | US | disclosed |