Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 15/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687905 | 0.89 | PTGER3 (0.46) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL687900 | 0.85 | PTGER3 (0.48) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL687968 | 0.84 | PTGER3 (0.42) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL688064 | 0.84 | PTGER3 (0.48) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL687685 | 0.84 | PTGER3 (0.48) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL688152 | 0.84 | LCK (0.42) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL688237 | 0.83 | KDM4E (0.46) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL688402 | 0.81 | PTGER3 (0.47) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL688196 | 0.80 | PIN1 (0.47) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL687418 | 0.80 | PTGER3 (0.46) | PTGER3ALDH1A1SMN1; SMN2KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |