Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CTSA | P10619 | 12/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688307 | 0.90 | MEN1 (0.38) | ITGB3ITGAVMEN1KMT2ACTSA | |
| SCHEMBL686898 | 0.88 | MEN1 (0.39) | ITGB3ITGAVMEN1KMT2ACTSA | |
| SCHEMBL687452 | 0.88 | KMT2A (0.38) | MEN1KMT2APOLBALDH1A1HPGD | |
| SCHEMBL688537 | 0.87 | KEAP1 (0.39) | ITGB3ITGAVMEN1KMT2AALDH1A1 | |
| SCHEMBL686847 | 0.87 | CTSA (0.40) | ITGB3ITGAVMEN1KMT2ACTSA | |
| SCHEMBL687910 | 0.87 | MEN1 (0.39) | ITGB3MEN1KMT2ACTSAALDH1A1 | |
| SCHEMBL688106 | 0.87 | KMT2A (0.41) | MEN1KMT2ACTSAALDH1A1HPGD | |
| SCHEMBL687500 | 0.87 | SMN1; SMN2 (0.37) | ITGB3ITGAVMEN1KMT2APOLB | |
| SCHEMBL688395 | 0.87 | MEN1 (0.37) | ITGB3ITGAVMEN1KMT2ACTSA | |
| SCHEMBL687271 | 0.86 | KMT2A (0.39) | ITGB3ITGAVMEN1KMT2ACTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |