Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.54 |
| ▸ | MMP2 | P08253 | 5/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888999 | 0.90 | ADAM17 (0.48) | ADAM17MMP2MMP1MMP9ADAM10 | |
| SCHEMBL6023772 | 0.87 | ADAM17 (0.61) | ADAM17MMP2MMP1MMP9ADAM10 | |
| SCHEMBL6023284 | 0.83 | ADAM17 (0.57) | ADAM17MMP2MMP1MMP9ADAM10 | |
| SCHEMBL6024346 | 0.80 | ADAM17 (0.47) | ADAM17MMP2MMP1MMP9MMP13 | |
| SCHEMBL6023575 | 0.80 | ADAM17 (0.50) | ADAM17MMP3 | |
| SCHEMBL6023809 | 0.80 | MMP13 (0.52) | ADAM17MMP2MMP1MMP9MMP13 | |
| SCHEMBL6023420 | 0.80 | ADAM17 (0.51) | ADAM17MMP2MMP9MMP13MMP3 | |
| SCHEMBL6023241 | 0.79 | ADAM17 (0.45) | ADAM17MMP2MMP13 | |
| SCHEMBL6022825 | 0.78 | ADAM17 (0.50) | ADAM17MMP2MMP13MMP3 | |
| SCHEMBL6022835 | 0.78 | ADAM17 (0.54) | ADAM17MMP2MMP1MMP9ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043349-A2 | ISOXAZOLINE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |