Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PYGM | P11217 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | TK2 | O00142 | 2/20 | 0.37 |
| ▸ | TK1 | P04183 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740177 | 0.84 | LMNA (0.47) | LMNASMN1; SMN2PYGMTSHRMAPT | |
| SCHEMBL6537910 | 0.82 | LMNA (0.46) | LMNASMN1; SMN2PYGMTSHRMAPT | |
| SCHEMBL6882254 | 0.81 | TK2 (0.56) | TSHRPMP22TK2TK1 | |
| SCHEMBL6882248 | 0.81 | TK2 (0.56) | TSHRPMP22TK2TK1 | |
| SCHEMBL6885381 | 0.80 | TK2 (0.45) | PYGMTSHRPMP22TK2TK1 | |
| SCHEMBL123663 | 0.77 | SLC28A1 (0.49) | P2RY6P2RY14 | |
| SCHEMBL35210374 | 0.75 | SLC28A1 (0.36) | PYGMP2RY14 | |
| SCHEMBL9769161 | 0.74 | LMNA (0.38) | LMNASMN1; SMN2PYGMTSHRMAPT | |
| SCHEMBL7617383 | 0.74 | LMNA (0.40) | LMNASMN1; SMN2PYGMTSHRMAPT | |
| SCHEMBL28551951 | 0.74 | LMNA (0.51) | LMNASMN1; SMN2TSHRMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |