Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 12/20 | 0.56 |
| ▸ | TK1 | P04183 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882254 | 1.00 | TK2 (0.56) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL6885381 | 0.90 | TK2 (0.45) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL31398394 | 0.86 | TK2 (0.56) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL6374680 | 0.86 | TK2 (0.56) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL3079836 | 0.82 | TK2 (0.52) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL6885486 | 0.81 | LMNA (0.46) | TK2TK1TSHRPMP22 | |
| SCHEMBL3087455 | 0.77 | TK1 (0.54) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL31439413 | 0.74 | TK2 (0.43) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL30396479 | 0.74 | TK2 (0.46) | TK2TK1CYP1A2CYP3A4TSHR | |
| SCHEMBL123663 | 0.73 | SLC28A1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |