Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azelastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 18/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 18/20 | 0.84 |
| ▸ | ADRA1B | P35368 | 18/20 | 0.84 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.84 |
| ▸ | HTR2A | P28223 | 2/20 | 0.84 |
| ▸ | DRD3 | P35462 | 2/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.84 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.84 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.84 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.84 |
| ▸ | HTR2C | P28335 | 1/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.84 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelastine SCHEMBL6886542 | 1.00 | ADRA1A (0.84) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL6887622 | 0.93 | ADRA1A (0.91) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL6887627 | 0.93 | ADRA1A (0.91) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL17223862 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4239 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4240 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL30910968 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL4433245 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL17803891 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL29370712 | 0.92 | ADRA1A (1.00) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017909-A | Salts of azelastine having improved solubility effective at treating psoriasis and providing a cytoprotective effect | ASTA PHARMA AG (DE) | 2000-01-25 | — | — | US | claimed |
| US-5998403-A | Salts of azelastine having improved solubility useful at providing a cytoprotective effect | ASTA PHARMA AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | claimed |
| US-5859003-A | ANTIALLERGENS, ANTIASTHMATICS | ASTA PHARMA AKTIENGESELLSCHAFT (DE) | 1999-01-12 | — | — | US | claimed |
| US-5086050-A | With acetic, gluconic, lactic or malic acids, administering | ASTA PHARMA AG (DE) | 1992-02-04 | — | — | US | claimed |
| US-20040198828-A1 | Using ketotifen and pheniramine | OPHTHALMIC RESEARCH ASSOCIATES, INC. | 2004-10-07 | — | — | US | disclosed |
| WO-2004069157-A2 | COMBINATIONAL USE OF LONG-ACTING AND SHORT-ACTING ANTI-HISTAMINES FOR OCULAR ALLERGIES | OPHTHALMIC RESEARCH ASSOCIATES, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| US-6017909-A | Salts of azelastine having improved solubility effective at treating psoriasis and providing a cytoprotective effect | ASTA PHARMA AG (DE) | 2000-01-25 | — | — | US | disclosed |
| US-5998403-A | Salts of azelastine having improved solubility useful at providing a cytoprotective effect | ASTA PHARMA AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | disclosed |
| US-5859003-A | ANTIALLERGENS, ANTIASTHMATICS | ASTA PHARMA AKTIENGESELLSCHAFT (DE) | 1999-01-12 | — | — | US | disclosed |
| US-5086050-A | With acetic, gluconic, lactic or malic acids, administering | ASTA PHARMA AG (DE) | 1992-02-04 | — | — | US | disclosed |