Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508090 | 0.90 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314363 | 0.89 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7900925 | 0.86 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7911130 | 0.85 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907983 | 0.85 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6886593 | 0.85 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7322059 | 0.84 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7314136 | 0.83 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8770460 | 0.83 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6758010 | 0.80 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |