Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11131467 | 0.89 | HRH3 (0.31) | HRH3HRH2 | |
| SCHEMBL19068672 | 0.82 | — | — | |
| SCHEMBL25445707 | 0.76 | — | — | |
| SCHEMBL203674 | 0.68 | GABRR1 (0.35) | — | |
| SCHEMBL14300615 | 0.68 | GABRR1 (0.35) | — | |
| SCHEMBL14534987 | 0.64 | GABRR1 (0.33) | — | |
| SCHEMBL22121326 | 0.64 | — | — | |
| Piperazine SCHEMBL14739784 | 0.63 | HIF1A (0.55) | — | |
| Piperazine SCHEMBL5946683 | 0.63 | HIF1A (0.55) | — | |
| Piperazine SCHEMBL2882663 | 0.63 | HIF1A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1426391-A1 | Aqueous polyurethane dispersions and their use for preparation of coatings that are permeable to water vapor | UCB, S.A. (BE) | 2004-06-09 | — | — | EP | disclosed |