Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL14739784 | 1.00 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5946683 | 1.00 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL3905641 | 0.96 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Ethylenediamine SCHEMBL1030825 | 0.95 | — | — | |
| Piperazine SCHEMBL3905644 | 0.92 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL9562685 | 0.84 | NFKB1 (0.54) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL2814299 | 0.84 | — | — | |
| Piperazine SCHEMBL4260232 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL4128881 | 0.81 | ALDH1A1 (0.64) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL22494138 | 0.81 | DNM1 (0.57) | HIF1AMAPTPDE4AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7758730-B2 | Method for improving a piperazine colour stability | BASF AKTIENGESELLSCHAFT (DE) | 2010-07-20 | — | — | US | claimed |
| EP-1752454-B1 | Method for separating piperazine from a mixture of ethylenediamine-piperazine through destillation | BASF SE (DE) | 2008-05-07 | — | — | EP | claimed |
| US-7271292-B2 | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AKTIENGESELLSCHAFT (DE) | 2007-09-18 | — | — | US | claimed |
| US-20070037980-A1 | under pressure at elevated temperature, by discharging the ethylenediamine at the top and the piperazine at the bottom of a distillation column | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-15 | — | — | US | claimed |
| CN-117645582-A | Ethylenediamine piperazine perchlorate and preparation method thereof | 西安近代化学研究所 | 2024-03-05 | — | — | CN | disclosed |
| CN-113514565-B | Method for detecting residues ethylenediamine and piperazine in homopiperazine | 昆药集团股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-113514565-A | Detection method of residual ethylenediamine and piperazine in homopiperazine | 昆药集团股份有限公司 | 2021-10-19 | — | — | CN | disclosed |
| CN-112110878-A | Flaky anhydrous piperazine crystal and preparation method thereof | 西安近代化学研究所 | 2020-12-22 | — | — | CN | disclosed |
| CN-104841479-B | A kind of compound solid-acid amination catalysis and preparation method thereof | 西安近代化学研究所 | 2017-09-08 | — | — | CN | disclosed |
| CN-104841479-A | Composite solid acid amination catalyst and preparation method thereof | XIAN MODERN CHEMISTRY RES INST | 2015-08-19 | — | — | CN | disclosed |
| CN-1911914-B | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AG | 2010-10-13 | — | — | CN | disclosed |
| CN-1911914-B | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AG | 2010-10-13 | — | — | CN | disclosed |
| US-7271292-B2 | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AKTIENGESELLSCHAFT (DE) | 2007-09-18 | — | — | US | disclosed |
| US-20070037980-A1 | under pressure at elevated temperature, by discharging the ethylenediamine at the top and the piperazine at the bottom of a distillation column | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-15 | — | — | US | disclosed |
| US-20070037980-A1 | under pressure at elevated temperature, by discharging the ethylenediamine at the top and the piperazine at the bottom of a distillation column | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-15 | — | — | US | disclosed |
| US-20070037980-A1 | under pressure at elevated temperature, by discharging the ethylenediamine at the top and the piperazine at the bottom of a distillation column | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-15 | — | — | US | disclosed |
| EP-1752454-A1 | Method for separating piperazine from a mixture of ethylenediamine-piperazine through destillation | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1752454-A1 | Method for separating piperazine from a mixture of ethylenediamine-piperazine through destillation | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-14 | — | — | EP | disclosed |
| CN-1911914-A | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AG (DE) | 2007-02-14 | — | — | CN | disclosed |
| CN-1911914-A | Process for distillatively removing piperazine from an ethylenediamine-piperazine mixture | BASF AG (DE) | 2007-02-14 | — | — | CN | disclosed |