Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL2882663 | 1.00 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL14739784 | 1.00 | HIF1A (0.55) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL3905641 | 0.96 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Ethylenediamine SCHEMBL1030825 | 0.95 | — | — | |
| Piperazine SCHEMBL3905644 | 0.92 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL9562685 | 0.84 | NFKB1 (0.54) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL2814299 | 0.84 | — | — | |
| Piperazine SCHEMBL4260232 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL4128881 | 0.81 | ALDH1A1 (0.64) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL22494138 | 0.81 | DNM1 (0.57) | HIF1AMAPTPDE4AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107952467-A | A kind of method for preparing catalyst of high selectivity piperazine triethylenediamine | 西安近代化学研究所 | 2018-04-24 | — | — | CN | claimed |
| EP-0842935-B1 | Process for the production of triethylenediamine | AIR PROD & CHEM (US) | 2003-05-07 | — | — | EP | claimed |
| CN-107952467-A | A kind of method for preparing catalyst of high selectivity piperazine triethylenediamine | 西安近代化学研究所 | 2018-04-24 | — | — | CN | disclosed |
| CN-107952467-A | A kind of method for preparing catalyst of high selectivity piperazine triethylenediamine | 西安近代化学研究所 | 2018-04-24 | — | — | CN | disclosed |
| CN-107952467-A | A kind of method for preparing catalyst of high selectivity piperazine triethylenediamine | 西安近代化学研究所 | 2018-04-24 | — | — | CN | disclosed |
| US-8512813-B2 | Coating composition, coating film made of same, and optical article | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2013-08-20 | — | — | US | disclosed |
| EP-1650275-B1 | COATING COMPOSITION, COATING FILM MADE OF SAME, AND OPTICAL ARTICLE | MITSUBISHI GAS CHEMICAL CO (JP) | 2013-06-26 | — | — | EP | disclosed |
| US-20120219807-A1 | COATING COMPOSITION, COATING FILM MADE OF SAME, AND OPTICAL ARTICLE | OKADA HIROYUKI (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20060167217-A1 | Coating composition, coating film made of same, and optical article | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1650275-A1 | COATING COMPOSITION, COATING FILM MADE OF SAME, AND OPTICAL ARTICLE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2006-04-26 | — | — | EP | disclosed |
| EP-0149186-B1 | PROCESS FOR PREVENTING AGGLOMERATION OF POWDERS | TOSOH CORPORATION (JP) | 1988-03-16 | — | — | EP | disclosed |
| US-4559384-A | Process for preventing agglomeration of powders by using triethylenediamine polymers | TOYO SODA MANUFACTURING CO., LTD. (JP) | 1985-12-17 | — | — | US | disclosed |
| EP-0149186-A2 | Process for preventing agglomeration of powders | TOSOH CORPORATION (JP) | 1985-07-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167217-A1 | Coating composition, coating film made of same, and optical article | TET1, FDFT1, TMT1A | HIF1A 2862/4885MAPT 374/4885PDE4A 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.