Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 6/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890934 | 0.94 | HRAS (0.56) | HRASITGB3ITGA2BKLKB1KLK1 | |
| SCHEMBL6890435 | 0.87 | HRAS (0.46) | HRASITGB3ITGA2BMAOBMEN1 | |
| SCHEMBL6884729 | 0.86 | HRAS (0.49) | HRASKLKB1KLK1 | |
| SCHEMBL7651482 | 0.85 | HRAS (0.70) | HRASITGB3ITGA2BMAOB | |
| SCHEMBL7941299 | 0.83 | HRAS (0.46) | HRASITGB3ITGA2B | |
| SCHEMBL6885242 | 0.83 | HRAS (0.46) | HRASITGB3ITGA2B | |
| SCHEMBL6885238 | 0.83 | HRAS (0.46) | HRASITGB3ITGA2B | |
| SCHEMBL6888605 | 0.82 | HRAS (0.53) | HRASITGB3ITGA2BKLKB1KLK1 | |
| SCHEMBL6890589 | 0.81 | HRAS (0.50) | HRASITGB3ITGA2B | |
| SCHEMBL7648759 | 0.80 | HRAS (0.62) | HRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |