Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 2/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.46 |
| ▸ | NMBR | P28336 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890435 | 0.95 | HRAS (0.46) | HRASSIRT2NMBRITGB3ITGA2B | |
| SCHEMBL6891485 | 0.90 | NMBR (0.49) | HRASSIRT2NMBR | |
| SCHEMBL6890934 | 0.86 | HRAS (0.56) | HRASITGB3ITGA2B | |
| SCHEMBL8588871 | 0.84 | SIRT2 (0.42) | HRASSIRT2NMBR | |
| SCHEMBL6887237 | 0.81 | HRAS (0.51) | HRASITGB3ITGA2B | |
| SCHEMBL6812617 | 0.79 | HRAS (0.53) | HRASSIRT2 | |
| SCHEMBL6812628 | 0.79 | HRAS (0.53) | HRASSIRT2 | |
| SCHEMBL6809104 | 0.79 | HRAS (0.53) | HRASSIRT2 | |
| SCHEMBL6809101 | 0.79 | HRAS (0.53) | HRASSIRT2 | |
| SCHEMBL6814437 | 0.77 | HRAS (0.52) | HRASSIRT2NMBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |