Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CDA | P32320 | 1/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801926 | 1.00 | LMNA (0.52) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL2803543 | 0.92 | LMNA (0.49) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL15011109 | 0.87 | LMNA (0.53) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL20668807 | 0.87 | LMNA (0.53) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL20668805 | 0.87 | LMNA (0.53) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL2801311 | 0.87 | LMNA (0.53) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL15010715 | 0.85 | LMNA (0.54) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL15010716 | 0.85 | LMNA (0.54) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL2801910 | 0.85 | SLC5A2 (0.49) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL20668770 | 0.84 | LMNA (0.53) | LMNAMTORALDH1A1TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |