Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887748 | 1.00 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7907997 | 0.85 | PDE4A (0.74) | PDE4A | |
| SCHEMBL7379831 | 0.85 | PDE4A (0.58) | PDE4A | |
| SCHEMBL7908346 | 0.81 | PDE4A (0.67) | PDE4A | |
| SCHEMBL6888609 | 0.76 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7397686 | 0.76 | PDE4A (0.61) | PDE4A | |
| SCHEMBL7400925 | 0.75 | PDE4A (0.59) | PDE4A | |
| SCHEMBL6890082 | 0.75 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7265252 | 0.75 | PDE4A (0.88) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6890078 | 0.75 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944599-B1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-0944599-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998028276-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |