Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959610 | 0.90 | MAOB (0.51) | MAOB | |
| SCHEMBL3208113 | 0.87 | KDM4E (0.44) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL4231254 | 0.86 | MAOB (0.51) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL5779644 | 0.85 | MAOB (0.57) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL4281014 | 0.84 | ABCB1 (0.52) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL28451865 | 0.84 | HDAC8 (0.55) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL6885591 | 0.83 | NPC1 (0.49) | HDAC8ABCB1HTR1ANPC1RAB9A | |
| SCHEMBL6885785 | 0.83 | PTGER1 (0.49) | MAOBHTR1ADRD2MAPTHTT | |
| SCHEMBL27563776 | 0.82 | MAOB (0.57) | HDAC8MAOBABCB1HTR1ADRD2 | |
| SCHEMBL6034576 | 0.81 | MAOB (0.55) | HDAC8MAOBABCB1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107868091-B | Meddigesin, derivatives thereof and preparation method thereof | 怀特生技新药股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | PHYTOHEALTH CORPORATION (TW) | 2019-08-20 | — | — | US | disclosed |
| CN-107868091-A | Meddigesin, derivatives thereof and preparation method thereof | 怀特生技新药股份有限公司 | 2018-04-03 | — | — | CN | disclosed |
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PHYTOHEALTH CORPORATION (TW) | 2018-03-29 | — | — | US | disclosed |
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PHYTOHEALTH CORPORATION (TW) | 2018-03-29 | — | — | US | disclosed |
| EP-3299373-A2 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | PhytoHealth Corporation (TW) | 2018-03-28 | — | — | EP | disclosed |
| WO-2004110351-A2 | HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS | ANADYS PHARMACEUTICALS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086772-A1 | MEDICARPIN, ITS DERIVATIVES, MANUFACTURING METHOD THEREOF | SHARPIN, TIPARP, MYADM | HDAC8 4603/4885MAOB 1213/4885ABCB1 1037/4885 |
| US-10385061-B2 | Medicarpin, its derivatives, manufacturing method thereof | SHARPIN, ATP6V1B1, REN | HDAC8 4358/4885MAOB 1618/4885ABCB1 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.