Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 11/20 | 0.37 |
| ▸ | CA2 | P00918 | 11/20 | 0.37 |
| ▸ | CA12 | O43570 | 10/20 | 0.37 |
| ▸ | CA4 | P22748 | 6/20 | 0.37 |
| ▸ | CA5A | P35218 | 6/20 | 0.37 |
| ▸ | CA7 | P43166 | 6/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886416 | 0.91 | TSHR (0.39) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6885027 | 0.89 | TSHR (0.38) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6885580 | 0.87 | TSHR (0.47) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6880949 | 0.87 | TSHR (0.36) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6882311 | 0.83 | LMNA (0.42) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6887860 | 0.80 | TSHR (0.37) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6888266 | 0.77 | TSHR (0.40) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6887838 | 0.76 | TSHR (0.49) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL6885775 | 0.74 | TSHR (0.47) | TSHRCA1CA2CA12CA4 | |
| SCHEMBL3702924 | 0.73 | CA2 (0.53) | CA1CA2CA12CA4CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |