Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 5/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903971 | 0.81 | GPR88 (0.44) | PARP15PARP10PARP2FFAR1CTSS | |
| SCHEMBL15146004 | 0.81 | GPR88 (0.44) | PARP15PARP10PARP2FFAR1CTSS | |
| SCHEMBL15146150 | 0.79 | PARP15 (0.44) | PARP15PARP10PARP2FFAR1CTSS | |
| SCHEMBL20969685 | 0.79 | PARP15 (0.50) | PARP15PARP10PARP2FFAR1CTSS | |
| SCHEMBL20969564 | 0.75 | PARP15 (0.51) | PARP15PARP10PARP2FFAR1CTSS | |
| SCHEMBL24618063 | 0.73 | PARP15 (0.53) | PARP15PARP10PARP2FNTAFNTB | |
| SCHEMBL20969745 | 0.73 | PARP15 (0.47) | PARP15PARP10PARP2KDM4EALDH1A1 | |
| SCHEMBL4427324 | 0.71 | PARP10 (0.51) | PARP15PARP10PARP2CTSSCTSL | |
| SCHEMBL20969688 | 0.70 | PARP15 (0.54) | PARP15PARP10PARP2FFAR1GPR88 | |
| SCHEMBL23355280 | 0.70 | PARP15 (0.53) | PARP15PARP10PARP2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486014-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2011044212-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |