Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2537598 | 0.81 | L3MBTL1 (0.54) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL27911792 | 0.81 | ALDH1A1 (0.63) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL6890022 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL27028359 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL24443463 | 0.78 | CCR1 (0.44) | RAB9AGRM5GRM4KDM4EPYGL | |
| SCHEMBL29689858 | 0.78 | CCR1 (0.44) | RAB9AGRM5GRM4KDM4EPYGL | |
| SCHEMBL177518 | 0.77 | KDM4C (0.62) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL30155195 | 0.77 | KDM4C (0.62) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL6888866 | 0.77 | L3MBTL1 (0.54) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 | |
| SCHEMBL21437805 | 0.77 | L3MBTL1 (0.54) | ALDH1A1MAPTL3MBTL1KDM4CNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483268-B1 | PYRIDINYL-IMIDAZOLONE DERIVATIVES FOR INHIBITING PI3 KINASES | MERCK PATENT GMBH (DE) | 2016-06-29 | — | — | EP | disclosed |
| US-8802866-B2 | Pyridinylimidazolone derivatives for the inhibition of PI3 kinases | MERCK PATENT GMBH (DE) | 2014-08-12 | — | — | US | disclosed |
| US-20120220587-A1 | PYRIDINYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF PI3 KINASES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-30 | — | — | US | disclosed |
| WO-2011035855-A1 | PYRIDINYL-IMIDAZOLONE DERIVATIVES FOR INHIBITING PI3 KINASES | MERCK PATENT GMBH (DE) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220587-A1 | PYRIDINYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF PI3 KINASES | PIK3R5, CDK20, PIK3R3 | ALDH1A1 4310/4885MAPT 3523/4885L3MBTL1 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.