Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473345 | 0.79 | — | — | |
| SCHEMBL1951658 | 0.77 | — | — | |
| SCHEMBL3503789 | 0.76 | PGD (0.41) | FDPSLMNAHSD17B10 | |
| SCHEMBL5014718 | 0.74 | FDPS (0.32) | FDPSCA1CA2 | |
| SCHEMBL18759575 | 0.74 | TSHR (0.52) | TSHR | |
| SCHEMBL28730023 | 0.74 | TSHR (0.52) | TSHR | |
| SCHEMBL8897631 | 0.74 | TSHR (0.52) | TSHR | |
| SCHEMBL17123002 | 0.73 | — | — | |
| SCHEMBL1609485 | 0.73 | — | — | |
| SCHEMBL4271862 | 0.73 | TSHR (0.58) | TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011062853-A1 | QUINOLIZIDINONE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-05-26 | — | — | WO | disclosed |