Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 20/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15145945 | 0.92 | GPR88 (0.72) | GPR88 | |
| SCHEMBL1666803 | 0.91 | GPR88 (0.74) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666648 | 0.88 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL14877724 | 0.88 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL6889750 | 0.87 | GPR88 (0.76) | GPR88 | |
| SCHEMBL1670661 | 0.81 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666650 | 0.81 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL14877718 | 0.81 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666810 | 0.80 | GPR88 (0.91) | GPR88 | |
| SCHEMBL14877710 | 0.80 | GPR88 (0.91) | GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486014-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2011044212-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |