Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.68 |
| ▸ | RAB9A | P51151 | 7/20 | 0.68 |
| ▸ | PKM | P14618 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346779 | 0.86 | NPC1 (0.73) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| Acetic Acid SCHEMBL3681231 | 0.86 | NPC1 (0.83) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL11666114 | 0.84 | RAB9A (0.56) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL10881647 | 0.83 | NPC1 (0.64) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL10799597 | 0.82 | NPC1 (0.63) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL4946651 | 0.81 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL27170422 | 0.81 | NPC1 (0.74) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL29611011 | 0.81 | NPC1 (1.00) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL5579208 | 0.81 | NPC1 (1.00) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL10115277 | 0.80 | NPC1 (0.85) | NPC1RAB9APKMSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57050960-A | — | — | None | — | — | JP | disclosed |
| JP-54032464-A | — | — | None | — | — | JP | disclosed |
| JP-53065871-A | — | — | None | — | — | JP | disclosed |
| JP-52156857-A | — | — | None | — | — | JP | disclosed |
| JP-55149255-A | — | — | None | — | — | JP | disclosed |
| US-20120083495-A1 | COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, | 2012-04-05 | — | — | US | disclosed |
| EP-1606248-B1 | SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE SPA (IT) | 2012-02-29 | — | — | EP | disclosed |
| US-8110681-B2 | Compounds for the treatment of spinal muscular atrophy and other uses | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-02-07 | — | — | US | disclosed |
| US-8110681-B2 | Compounds for the treatment of spinal muscular atrophy and other uses | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-02-07 | — | — | US | disclosed |
| US-7737139-B2 | Sulfonic acids, their derivatives and pharmaceutical compositions containing them | DOMPE PHA.R.MA S.P.A. (IT) | 2010-06-15 | — | — | US | disclosed |
| EP-1457485-A1 | Sulfonic acids, their derivatives and pharmaceutical compositions containing them | Dompé S.P.A. (IT) | 2004-09-15 | — | — | EP | disclosed |
| US-5112846-A | Nonsteroidal antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1992-05-12 | — | — | US | disclosed |
| US-5075330-A | N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents | WARNER-LAMBERT CO. (US) | 1991-12-24 | — | — | US | disclosed |
| US-4981865-A | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents | WARNER-LAMBERT CO. (US) | 1991-01-01 | — | — | US | disclosed |
| JP-S5750960-A | PREPARATION OF NOVEL 4- 1-OXO-2-ISOINDOLINYL ACETOPHENONE | HISAMITSU PHARMACEUT CO INC | 1982-03-25 | — | — | JP | disclosed |
| JP-S55149255-A | PREPARATION OF NOVEL 4-(1-OXO-2-ISOINDOLINYL)ACETOPHENONE | HISAMITSU PHARMACEUT CO INC | 1980-11-20 | — | — | JP | disclosed |
| US-4166125-A | ANTIINFLAMMATORY AGENTS; LOW TOXICITY ANALGESIC, ANTIPYRETIC | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1979-08-28 | — | — | US | disclosed |
| JP-S5432464-A | PREPARATION OF 4-(1-OXO-2-ISOINDOLINYL)-ACETOPHENONE | GRELAN PHARMACEUT CO LTD | 1979-03-09 | — | — | JP | disclosed |
| JP-S5365871-A | PREPARATION OF 4-(1-OXO-2-ISOINDONYL)ACETOPHENONE | GRELAN PHARMACEUT CO LTD | 1978-06-12 | — | — | JP | disclosed |
| JP-S52156857-A | 4-(1-OXO-2-ISOINDOLINYL)ACETOPHENONE AND ITS PREPARATION | GRELAN PHARMACEUT CO LTD | 1977-12-27 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083495-A1 | COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | SMN1; SMN2, RNMT, CPT1B | NPC1 1076/4885RAB9A 1487/4885PKM 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.