Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10896997 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4958371 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL725546 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL842 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1332229 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28641702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1331942 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3417188 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL240402 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27588807 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115488130-A | Decommissioning photovoltaic module disassembling method based on low-temperature pyrolysis | 常州工学院 | 2022-12-20 | — | — | CN | claimed |
| JP-6310425-A | — | — | None | — | — | JP | disclosed |
| JP-8319558-A | — | — | None | — | — | JP | disclosed |
| CN-116806843-A | Antibacterial composite powder material and preparation method thereof | 广州市科瑨材料科技有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116177620-A | Method for regenerating and synthesizing positive electrode material precursor by using waste ternary lithium battery | 四川蜀矿环锂科技有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-115488130-A | Decommissioning photovoltaic module disassembling method based on low-temperature pyrolysis | 常州工学院 | 2022-12-20 | — | — | CN | disclosed |
| CN-111426738-B | Electrochemical in-situ monitoring device and method for soil/underground water remediation process | 华中师范大学 | 2022-12-02 | — | — | CN | disclosed |
| CN-113430509-B | Anticorrosive treatment process for stainless steel pipe fitting | 浙江固的管业有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-111640814-B | Solar cell structure and preparation method thereof | 天津三安光电有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-113594297-A | Method for regulating and controlling energy band structure of quantum well and quantum dot material | 复旦大学 | 2021-11-02 | — | — | CN | disclosed |
| WO-2002048748-A2 | CURRENT LEVELING LAYER INTEGRATED WITH APERTURE FOR INTRACAVITY DEVICE | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE (US) | 2002-06-20 | — | — | WO | disclosed |
| US-20020071464-A1 | Contact scheme for intracavity-contacted vertical-cavity surface-emitting laser | DARPA | 2002-06-13 | — | — | US | disclosed |
| WO-2002017360-A1 | DOUBLE INTRACAVITY CONTACTED LONG-WAVELENGTH VCSELS AND METHOD OF FABRICATING SAME | REGENT OF THE UNIVERSITY OF CALIFORNIA, THE (US) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002017446-A1 | CONTACT SCHEME FOR INTRACAVITY-CONTACTED VERTICAL-CAVITY SURFACE-EMITTING LASER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002017449-A1 | DOUBLE INTRACAVITY CONTACTED LONG-WAVELENGTH VCSELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-02-28 | — | — | WO | disclosed |
| US-20020025589-A1 | Double intracavity contacted long-wavelength VCSELs and method of fabricating same | DARPA | 2002-02-28 | — | — | US | disclosed |
| JP-H08319558-A | BACK METAL FORMING SUBSTRATE AND BACK METAL FORMING METHOD | OKI ELECTRIC IND CO LTD | 1996-12-03 | — | — | JP | disclosed |
| JP-H06310425-A | METHOD FOR FORMING QUANTUM WIRE | SANYO ELECTRIC CO LTD | 1994-11-04 | — | — | JP | disclosed |
| US-4829347-A | Process for making indium gallium arsenide devices | AMERICAN TELEPHONE AND TELEGRAPH COMPANY, AT&T BELL LABORATORIES (US) | 1989-05-09 | — | — | US | disclosed |
| US-4065544-A | Finely divided metal oxides and sintered objects therefrom | UNION CARBIDE CORPORATION (US) | 1977-12-27 | — | — | US | disclosed |