Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889868 | 1.00 | AAK1 (0.53) | AAK1MMP13RENCTSLCTSB | |
| SCHEMBL6888134 | 0.86 | REN (0.46) | AAK1MMP13RENCTSLCTSB | |
| SCHEMBL6888131 | 0.86 | REN (0.46) | AAK1MMP13RENCTSLCTSB | |
| SCHEMBL30807693 | 0.81 | AAK1 (0.60) | AAK1MMP13RENCTSLCTSB | |
| SCHEMBL18414177 | 0.79 | AAK1 (0.56) | AAK1MMP13RENCTSLCTSB | |
| SCHEMBL6892246 | 0.79 | MAOB (0.44) | MMP13REN | |
| SCHEMBL25288616 | 0.78 | CTSK (0.53) | AAK1RENCTSLCTSBCTSS | |
| SCHEMBL25288617 | 0.78 | CTSK (0.53) | AAK1RENCTSLCTSBCTSS | |
| SCHEMBL29052582 | 0.76 | CTSK (0.50) | AAK1RENCTSLCTSBCTSS | |
| SCHEMBL31512916 | 0.76 | REN (0.59) | AAK1MMP13REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |