Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.92 |
| ▸ | TSHR | P16473 | 1/20 | 0.92 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | BAX | Q07812 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL2886896 | 1.00 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL28009593 | 0.96 | LTA4H (0.86) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL2461810 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL4950525 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL12286 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL9061108 | 0.96 | LTA4H (1.00) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11437630 | 0.93 | LTA4H (0.80) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL11777679 | 0.92 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| Diphenylether SCHEMBL18096784 | 0.92 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA | |
| SCHEMBL22129853 | 0.92 | LTA4H (0.92) | LTA4HTSHRNR1H2BAXMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974133-A | Two part room temperature curable heat and flame resistant composition | 汉高股份有限及两合公司 | 2024-11-15 | — | — | CN | claimed |
| CN-111574493-A | Preparation method of bromide of substituted diphenyl ether | 青岛凯源祥化工有限公司 | 2020-08-25 | — | — | CN | claimed |
| JP-57000168-A | — | — | None | — | — | JP | disclosed |
| JP-63289998-A | — | — | None | — | — | JP | disclosed |
| JP-51128929-A | — | — | None | — | — | JP | disclosed |
| US-11912654-B2 | Process for stereospecific synthesis of vitamin K2 and its novel intermediates | SYNERGIA LIFE SCIENCES PVT. LTD. (IN) | 2024-02-27 | — | — | US | disclosed |
| WO-2024013633-A1 | PROCESS FOR THE SYNTHESIS OF VITAMIN K2 | SYNERGIA LIFE SCIENCES PVT. LTD. (IN) | 2024-01-18 | — | — | WO | disclosed |
| CN-116332734-A | Preparation method of m-phenoxybenzyl alcohol | 江苏扬农化工股份有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-218890158-U | Cooling crystallizer for producing difenoconazole | 江苏莱科化学有限公司 | 2023-04-21 | — | — | CN | disclosed |
| US-20230093176-A1 | PROCESS FOR STEREOSPECIFIC SYNTHESIS OF VITAMIN K2 AND ITS NOVEL INTERMEDIATES | SYNERGIA LIFE SCIENCES PVT. LTD. (IN) | 2023-03-23 | — | — | US | disclosed |
| US-11407704-B2 | Process of vitamin K2 derivatives preparation | SIEC BADAWCZA LUKASIEWICZ-INSTYTUT CHEMII PRZEMYSLOWEJ IMIENIA PROFESORA IGNACEGO MOSCICKIEGO (PL) | 2022-08-09 | — | — | US | disclosed |
| CN-1279232-A | Process for whitening decabromodiphenyl ether and its product | GU HAO (CN) | 2001-01-10 | — | — | CN | disclosed |
| US-6063848-A | CONTAINS FIBROUS FILLERS SELECTED FROM WOLLASTONITE, POTASSIUM TITANATE HAVING SPECIFIED DIAMETERS AND ASPECT RATIOS; LOW COEFFICIENT OF EXPANSION; ELECTRONICS, ADHESION OF POLYMERS TO METAL | POLYPLASTICS CO., LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0645430-B1 | Thermoplastic resin composition | DAI ICHI KOGYO SEIYAKU CO LTD (JP) | 1999-05-26 | — | — | EP | disclosed |
| US-5654369-A | ADDITION POLYMER BLEND COMPRISING A COPOLYMER WITH ANTISTATIC FUNCTIONAL GROUPS PROVIDES UNIFORM AND PERMANENT ANTISTATIC PROPERTIES TO MOLDED MATERIALS; PACKAGING MATERIALS; ELECTRONIC PARTS | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0755983-A2 | Thermoplastic resin composition | DAI-ICHI KOGYO SEIYAKU CO., LTD. (JP) | 1997-01-29 | — | — | EP | disclosed |
| JP-S63289998-A | MULTILAYER CIRCUIT SUBSTRATE | MATSUSHITA ELECTRIC WORKS LTD | 1988-11-28 | — | — | JP | disclosed |
| US-4327227-A | CATALYZED BROMINATION OF DIPHENYL ETHER | GREAT LAKES CHEMICAL CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |
| JP-S57168-A | FLAME-RETARDANT PLASTIC COMPOSITION | MATSUSHITA ELECTRIC WORKS LTD | 1982-01-05 | — | — | JP | disclosed |
| JP-S51128929-A | PROCESS FOR PREPARING LIGHT STABLE DIPHENYLETHER BROMIDE PROCESS FOR PREPARING LIGHT STABLE DIPHENYLETHER BROMIDE | MITSUI TOATSU CHEM INC | 1976-11-10 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912654-B2 | Process for stereospecific synthesis of vitamin K2 and its novel intermediates | PROC, VKORC1, NADK | LTA4H 1854/4885TSHR 4646/4885NR1H2 2558/4885 |
| US-11407704-B2 | Process of vitamin K2 derivatives preparation | PROC, VKORC1, VKORC1L1 | LTA4H 3232/4885TSHR 4386/4885NR1H2 1192/4885 |
| US-20230093176-A1 | PROCESS FOR STEREOSPECIFIC SYNTHESIS OF VITAMIN K2 AND ITS NOVEL INTERMEDIATES | PROC, VKORC1, NADK | LTA4H 1854/4885TSHR 4646/4885NR1H2 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.