SCHEMBL6890048

SCHEMBL6890048

N#Cc1ccc(CN2CCN(S(=O)(=O)/C=C/c3ccc(Cl)cc3)CC2=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F10 P00742 8/20 0.54
ALDH1A1 P00352 3/20 0.41
FNTA P49354 2/20 0.40
FNTB P49356 2/20 0.40
PGGT1B P53609 1/20 0.38
CNR1 P21554 1/20 0.37
KMT2A Q03164 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
MAPK1 P28482 2/20 0.37
LMNA P02545 1/20 0.37
MEN1 O00255 2/20 0.37
MAPT P10636 1/20 0.36
USP2 O75604 1/20 0.36
CYP3A4 P08684 1/20 0.36
HIF1A Q16665 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6890055 1.00 F10 (0.54) F10ALDH1A1FNTAFNTBPGGT1B
SCHEMBL6896200 0.81 CYP3A4 (0.41) F10ALDH1A1FNTAFNTBCNR1
Hydrochloric Acid SCHEMBL6893030 0.81 F10 (0.56) F10ALDH1A1KMT2ASMN1; SMN2MAPK1
SCHEMBL6892965 0.77 USP2 (0.47) F10ALDH1A1FNTAFNTBCNR1
SCHEMBL6894345 0.76 CYP3A4 (0.42) F10ALDH1A1FNTAFNTBCNR1
SCHEMBL6895154 0.74 F10 (0.49) F10FNTAFNTBCNR1KMT2A
SCHEMBL6894382 0.73 USP2 (0.47) F10ALDH1A1FNTAFNTBCNR1
SCHEMBL6893809 0.71 F10 (0.44) F10FNTAFNTBCNR1
SCHEMBL1194653 0.71 MAOB (0.43) CNR1KMT2ALMNAMEN1MAPT
SCHEMBL1194652 0.71 MAOB (0.43) CNR1KMT2ALMNAMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6680312-B2 FOR THERAPY OF CARDIAC INFARCTION, CEREBRAL THROMBOSIS; INHIBIT ACTIVATED COAGULATION FACTOR X (FXA) TO SHOW ANTI-COAGULANT ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2004-01-20 US disclosed
US-20020193382-A1 Sulfonamide derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) 2002-12-19 US disclosed
US-6403595-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-06-11 US disclosed
EP-1054005-A1 SULFONAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020193382-A1 Sulfonamide derivatives, their production and use F12, F11, F2 F10 5/4885ALDH1A1 2304/4885FNTA 2027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.