Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055209 | 0.86 | LMNA (0.69) | LMNAMAPK1ALOX15SMN1; SMN2HTT | |
| SCHEMBL27715515 | 0.77 | HTT (0.56) | LMNASMN1; SMN2HTTMAPTPOLB | |
| SCHEMBL1852463 | 0.73 | KMT2A (0.56) | LMNAMAPK1ALOX15HTTALDH1A1 | |
| SCHEMBL27851630 | 0.73 | HTT (0.47) | SMN1; SMN2HTTMAPTPOLBKMT2A | |
| SCHEMBL19951196 | 0.71 | LMNA (0.59) | LMNAMAPK1ALOX15SMN1; SMN2HTT | |
| SCHEMBL19951198 | 0.71 | ABHD6 (0.60) | LMNAMAPK1ALOX15SMN1; SMN2MAPT | |
| SCHEMBL29865385 | 0.70 | HTT (0.65) | HTTALDH1A1POLBKMT2ACYP2D6 | |
| SCHEMBL2360580 | 0.70 | SMN1; SMN2 (0.47) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8444618 | 0.70 | POLB (1.00) | LMNAMAPK1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1554013 | 0.69 | SLC22A12 (0.73) | POLBKMT2AMEN1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082079-A1 | Low affinity screening method | GRAFFINITY PHARMACEUTICALS AG. (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |