Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039031 | 0.83 | GAA (0.97) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL6894140 | 0.83 | GAA (0.51) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL14507610 | 0.82 | GAA (1.00) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL2744764 | 0.82 | ALDH1A1 (0.70) | GAASMN1; SMN2MAPTMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3351627 | 0.82 | GAA (0.50) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL2744997 | 0.81 | USP2 (0.69) | GAASMN1; SMN2LMNAMAPTMAPK1 | |
| Cyclohexane SCHEMBL8463889 | 0.77 | LCK (0.57) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL3348685 | 0.77 | GLA (0.73) | GAASMN1; SMN2LMNATSHRHTT | |
| SCHEMBL27510172 | 0.74 | LCK (0.64) | GAASMN1; SMN2LMNATSHRMAPT | |
| SCHEMBL8374211 | 0.73 | KDM4E (0.56) | GAALMNATSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |