Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.59 |
| ▸ | APP | P05067 | 11/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931281 | 0.95 | BACE1 (0.60) | BACE1KCNH2BACE2APP | |
| SCHEMBL932626 | 0.93 | BACE1 (0.65) | BACE1KCNH2BACE2APP | |
| SCHEMBL932205 | 0.86 | BACE1 (0.61) | BACE1KCNH2BACE2APP | |
| SCHEMBL932073 | 0.85 | BACE1 (0.59) | BACE1KCNH2BACE2APP | |
| SCHEMBL6891103 | 0.80 | BACE1 (0.56) | BACE1KCNH2BACE2 | |
| SCHEMBL932191 | 0.78 | BACE1 (0.51) | BACE1KCNH2BACE2APP | |
| SCHEMBL931600 | 0.78 | BACE1 (0.55) | BACE1KCNH2BACE2APP | |
| SCHEMBL931210 | 0.77 | BACE1 (0.47) | BACE1KCNH2BACE2APP | |
| SCHEMBL18927263 | 0.77 | BACE1 (0.44) | BACE1KCNH2BACE2APP | |
| SCHEMBL945501 | 0.77 | BACE1 (0.47) | BACE1KCNH2BACE2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |