Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718222 | 1.00 | TSHR (0.39) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL17677168 | 0.95 | TSHR (0.35) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL14619487 | 0.86 | PLA2G1B (0.35) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL28966747 | 0.84 | CYP1A2 (0.42) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL29046390 | 0.84 | CYP1A2 (0.42) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL1147342 | 0.83 | TSHR (0.44) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL7530841 | 0.83 | GABRR1 (0.39) | TSHRGABRR1GABBR2GABBR1LMNA | |
| SCHEMBL9054773 | 0.83 | GABRR1 (0.39) | TSHRGABRR1GABBR2GABBR1LMNA | |
| SCHEMBL9345722 | 0.81 | TSHR (0.32) | TSHRNPY1RNPY2RL3MBTL1PLA2G1B | |
| SCHEMBL8601781 | 0.79 | GABRR1 (0.34) | TSHRGABRR1GABBR2GABBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | claimed |
| EP-1370554-A1 | 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2003-12-17 | — | — | EP | claimed |
| US-6653308-B2 | Anticancer agents; antidiabetic agents; antiinflammatory agents | SUGEN, INC. | 2003-11-25 | — | — | US | claimed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | claimed |
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | claimed |
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. | 2003-07-03 | — | — | US | claimed |
| EP-0512879-B2 | Cosmetic composition containing odour-free alkalizing agent | OREAL (FR) | 2003-06-04 | — | — | EP | claimed |
| WO-2002066463-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2002-08-29 | — | — | WO | claimed |
| US-5628991-A | Cosmetic composition containing a diaminoalkane as an odorless alkalifying agent | L'OREAL (FR) | 1997-05-13 | — | — | US | claimed |
| US-20220388962-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | FOX CHASE CHEMICAL DIVERSITY CENTER INC. | 2022-12-08 | — | — | US | disclosed |
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114667145-A | Molecules that bind to TDP-43 for the treatment of amyotrophic lateral sclerosis and related disorders | 拜尔哈文制药股份有限公司 | 2022-06-24 | — | — | CN | disclosed |
| WO-2021035101-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | BIOHAVEN THERAPEUTICS LTD. (US) | 2021-02-25 | — | — | WO | disclosed |
| US-20140221455-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | Verva Pharmaceuticals, Inc. (AU) | 2014-08-07 | — | — | US | disclosed |
| US-4112105-A | Anti-inflammatory 3-(substituted-amino)-2,1-benzisothiazoles | STERLING DRUG INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4055393-A | TEXTILE FINISHING | CIBA-GEIGY CORPORATION (US) | 1977-10-25 | — | — | US | disclosed |
| US-4038233-A | AQUEOUS RESIN COMPOSITION CONTAINING POLYMERS OR COPOLYMERS OF ETHYLENICALLY UNSATURATED MONOMERS AND A WATER-SOLUBLE CATIONIC POLYELECTROLYTE POLYMER | JOHNSON & JOHNSON (US) | 1977-07-26 | — | — | US | disclosed |
| US-3997538-A | BACTERICIDE | MORTON-NORWICH PRODUCTS, INC. (US) | 1976-12-14 | — | — | US | disclosed |
| US-3992366-A | FOR CROSSLINKING PHOTOGRAPHIC GELATINS | CIBA-GEIGY AG (CH) | 1976-11-16 | — | — | US | disclosed |
| US-3979405-A | HYPOLIPEMIC AND HYPOCHOLESTERIC AGENTS | GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1976-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220388962-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | TARDBP, TDP1, TDP2 | TSHR 4276/4885NPY1R 3710/4885NPY2R 4325/4885 |
| US-20030125370-A1 | 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | DMPK, ADK, MAP3K20 | TSHR 3115/4885NPY1R 3462/4885NPY2R 3323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.