Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | KIF5B | P33176 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ETV6 | P41212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238830 | 0.89 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8RET | |
| SCHEMBL1023167 | 0.85 | DGAT1 (0.37) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL1074751 | 0.83 | DGAT1 (0.41) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL6891477 | 0.82 | — | — | |
| SCHEMBL2680179 | 0.82 | GPR119 (0.40) | DGAT1 | |
| SCHEMBL10328346 | 0.80 | DGAT1 (0.39) | DGAT1MTORRPTORMLST8RET | |
| SCHEMBL7883028 | 0.79 | DGAT1 (0.41) | DGAT1MTORRPTORMLST8RET | |
| SCHEMBL15026290 | 0.79 | CHEK1 (0.40) | DGAT1MTORRPTORMLST8RET | |
| SCHEMBL588542 | 0.78 | DGAT1 (0.39) | DGAT1RETKIF5BKDRETV6 | |
| SCHEMBL14298310 | 0.78 | DGAT1 (0.40) | DGAT1MTORRPTORMLST8RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |