Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892507 | 1.00 | BACE1 (0.52) | BACE1APPKCNH2CTSDBACE2 | |
| SCHEMBL931789 | 1.00 | BACE1 (0.52) | BACE1APPKCNH2CTSDBACE2 | |
| SCHEMBL946753 | 0.76 | BACE1 (0.62) | BACE1APPKCNH2BACE2 | |
| SCHEMBL6892614 | 0.76 | BACE1 (0.62) | BACE1APPKCNH2BACE2 | |
| SCHEMBL6894146 | 0.76 | BACE1 (0.56) | BACE1APPKCNH2ALDH1A1 | |
| SCHEMBL3776518 | 0.70 | BACE1 (0.59) | BACE1APPKCNH2CTSDBACE2 | |
| SCHEMBL932353 | 0.70 | BACE1 (0.69) | BACE1KCNH2BACE2 | |
| SCHEMBL931592 | 0.69 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL932732 | 0.69 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL2086507 | 0.69 | BACE1 (0.52) | BACE1APPKCNH2CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |