Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932149 | 0.82 | BACE1 (1.00) | BACE1KCNH2MEN1PSIP1AXL | |
| SCHEMBL932295 | 0.80 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL946753 | 0.78 | BACE1 (0.62) | BACE1KCNH2BACE2 | |
| SCHEMBL6892614 | 0.78 | BACE1 (0.62) | BACE1KCNH2BACE2 | |
| SCHEMBL932452 | 0.76 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL932309 | 0.75 | BACE1 (0.44) | BACE1KCNH2 | |
| SCHEMBL932732 | 0.74 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL931592 | 0.74 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL931835 | 0.74 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL932287 | 0.74 | BACE1 (0.75) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |