Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328252 | 0.93 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL1023126 | 0.93 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL2725210 | 0.92 | DGAT1 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL10277454 | 0.91 | GPR119 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL10277457 | 0.91 | GPR119 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL10277456 | 0.91 | GPR119 (0.38) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL15807825 | 0.89 | MTOR (0.43) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL14661102 | 0.89 | MTOR (0.43) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL1082162 | 0.89 | DGAT1 (0.43) | DGAT1MTORRPTORMLST8 | |
| SCHEMBL1082158 | 0.89 | DGAT1 (0.43) | DGAT1MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-07-12 | — | — | US | disclosed |
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MTOR, RICTOR, RPTOR | DGAT1 3898/4885MTOR 1/4885RPTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.