Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892030 | 0.92 | CHRM1 (0.52) | CHRM1BRD4GABRA5RAB9ASCN9A | |
| SCHEMBL2222077 | 0.88 | CHRM1 (0.55) | CHRM1ADAM17 | |
| SCHEMBL2275591 | 0.85 | CHRM1 (0.53) | CHRM1BRD4KMT2A | |
| SCHEMBL6890113 | 0.85 | CHRM1 (0.49) | CHRM1BRD4RAB9AADAM17MAPK1 | |
| SCHEMBL6890080 | 0.81 | BRD4 (0.47) | CHRM1BRD4GABRA5RAB9AADAM17 | |
| SCHEMBL6889896 | 0.81 | CHRM1 (0.78) | CHRM1BRD4 | |
| SCHEMBL21935353 | 0.80 | CHRM1 (0.47) | CHRM1BRD4GABRA5RAB9AKMT2A | |
| SCHEMBL6890674 | 0.80 | CHRM1 (0.49) | CHRM1BRD4GABRA5RAB9A | |
| SCHEMBL2222670 | 0.80 | CHRM1 (0.56) | CHRM1ADAM17 | |
| SCHEMBL2223326 | 0.80 | CHRM1 (0.56) | CHRM1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |