Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP10 | P09238 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224783 | 0.87 | CHRM1 (0.54) | CHRM1ADAM17MMP3MMP7MMP10 | |
| SCHEMBL6891432 | 0.85 | CHRM1 (0.51) | CHRM1BRD4MAPK1ADAM17RAB9A | |
| SCHEMBL2275591 | 0.84 | CHRM1 (0.53) | CHRM1BRD4 | |
| SCHEMBL6892030 | 0.84 | CHRM1 (0.52) | CHRM1BRD4ADAM17MMP3MMP7 | |
| SCHEMBL12803234 | 0.83 | CHRM1 (0.53) | CHRM1ADAM17 | |
| SCHEMBL6890080 | 0.80 | BRD4 (0.47) | CHRM1BRD4LMNAMAPK1ADAM17 | |
| SCHEMBL6890076 | 0.80 | KCNH2 (0.48) | LMNARAB9A | |
| SCHEMBL6889946 | 0.80 | IGFBP5 (0.46) | LMNA | |
| SCHEMBL6889896 | 0.80 | CHRM1 (0.78) | CHRM1BRD4 | |
| SCHEMBL6890837 | 0.79 | CHRM1 (0.69) | CHRM1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |